Other investigators have reported that cyclophosphamide increased the expression of Bax, which is a stimulator of apoptosis, in most of the prostatic acini of rats; however, the cyclophosphamide-induced change in Bax expression was improved by the concomitant administration of CDDP and RJ [51]. Protective effect of royal jelly in 2,4,6 trinitrobenzene sulfonic acid-induced colitis in rats. The .gov means its official. All three scores of fatigue and performance status in the study group were significantly better than those in control group [63]; however, the authors indicated that further clinical trials with a larger number of patients and a longer duration of intervention are necessary to clarify the role of RJ in managing cancer-related fatigue, because their study populations included a variety of malignancies and treatments. In this study, RJ administration led to a decrease in the malondialdehyde level and an increase in superoxide dismutase, catalase and glutathione-peroxidase activities; in addition, the authors commented that RJ may suppress CDDP-induced sperm toxicity owing to its antioxidant activities. The current study investigated the anti-inflammory function of 10-HDA on human colon cancer cells, WiDr, as well as its effect on the growth of pathogenic . 5. Effects against oxidative stress are attributed to antioxidant peptides(24). Oral intake of royal jelly improves anti-cancer effects and suppresses However, when the clinical trials of RJ-based therapy are planned, the administration method may be an important determinant of its success. In this review, we have summarized studies on the anti-cancer effects of RJ reported in in vivo and in vitro studies. However, a similar significant improvement of kidney function parameters was not found in RJ group. In contrast, although we already stated that RJ could inhibit the bisphenol-induced proliferation of breast cancer cells, 10-HDA does not exhibit similar anti-proliferative activity [25]. Furthermore, this study suggested that a decrease in prostaglandin E (PGE)-2 might be associated with such anti-cancer effects in addition to immunity-related host resistance [30]. Therefore, in this section, we have discussed the reported anti-cancer effects of RJ and 10-HDA in various malignancies. Taguchi T., Nazneen A., Abid M.R., Razzaque M.S. Le Saux O., Falandry C. Toxicity of Cancer Therapies in Older Patients. The authors received the fund from Yamada Research Grant; however, this review received no financial or technical support from this grant. In addition, these anti-cancer effects of RJ were mediated via the suppression of estradiol-related signaling in cell proliferation but not by binding of estradiol to the estrogen receptor [25]. Kolayli S., Sahin H., Can Z., Yildiz O., Malkoc M., Asadov A. In patients with advanced or metastatic tumors, systematic therapies with anti-cancer agents are usually fundamental treatment strategies; however, the anti-cancer effects, including prolongation of survival, of such systematic therapies are not always satisfactory in clinical practice. The interaction of bee products with temozolomide in human diffuse astrocytoma, glioblastoma multiforme and astroglia cell lines. In fact, CDDP remarkably increased the expression of caspase-3, which is a key mediator of apoptosis, in the kidney and liver of rats. Effects produced by Royal Jelly on haematopoiesis: Relation with host resistance against Ehrlich ascites tumour challenge. Assessment of the floral origin of honey by SDS-page immunoblot techniques. Call us at 833-347-1665 to make an appointment. In short, the highest protection conferred an extension of survival of approximately 38%, 71% and 85% for doses of 0.5, 1.0 and 1.5 g/kg for 33 days, respectively. Oka H., Emori Y., Kobayashi N., Hayashi Y., Nomoto K. Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses. For example, in patients with head and neck cancer, a randomized single (physician)-blind trial with an RJ-treated group (n = 7) and a control group (n = 6) was performed to evaluate the clinical utility of RJ for the prevention of oral and esophageal mucositis [59]. Effect of Royal Jelly on premenstrual syndrome among Iranian medical sciences students: a randomized, triple-blind, placebo-controlled study. 8600 Rockville Pike Molecular-level changes induced by royal jelly in response to anti-cancer therapies. Effect of Processed Honey and Royal Jelly on Cancer-Related Thus, there is a consensus that RJ is safe as a supplement and drug for clinical use under proper conditions. Briefly, the combination of TMZ with honey, beebread and RJ, exerted stronger cytotoxic activity on human glioblastoma multiforme cells (U87MG) than TMZ alone. In menopause, the most prevalent is breast cancer and royal jelly demonstrated its ability as a complementary therapy in cancer. The content of 10-HDA in RJ is reported to be 0.8%6.5%; moreover, it is known as a unique component of RJ because it is not detected in any other natural raw material, even in other bee products [11,22,38]. Valko M., Rhodes C.J., Moncol J., Izakovic M., Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Kobayashi N., Unten S., Kakuta H., Komatsu N., Fujimaki M., Satoh K., Aratsu C., Nakashima H., Kikuchi H., Ochiai K., et al. However, it is possibility that this mechanism may affect the pathological mechanisms of some toxicities owing to the important role of eNOS in endothelial cell survival and angiogenesis [74]. Decreasing the incidence and severity of adverse events induced by anti-cancer therapies is of great importance for the maintenance of the quality of life (QOL) of patients with cancer. Therapeutic Properties of Bioactive Compounds from Different Honeybee Products. Several clinical studies have confirmed the efficacy of RJ against drug-induced toxicities and clarified the mechanisms in patients with cancer; however, almost all of these clinical trials used relatively small study populations. Royal Jelly: Beneficial Properties and Synergistic Effects with Bommareddy A., Knapp K., Nemeth A., Steigerwalt J., Landis T., Vanwert A.L., Gorijavolu H.P., Dwivedi C. Alpha-Santalol, a component of sandalwood oil inhibits migration of breast cancer cells by targeting the -catenin pathway. These reports do not indicate that RJ has significant toxicities or propensity to cause adverse events; however, more detailed and broader information on the biological effects of RJ at molecular, pathological and clinical levels should be collected for normal cells, tissues and organs. Indeed, as mentioned above, inhibitory effects, such as the prevention of tumor growth and invasion, have been confirmed by in vivo and in vitro studies. Silici S., Ekmekcioglu O., Kanbur M., Deniz K. The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats. It is also important for the improvement of anti-cancer effects and the prolongation of survival: essentially, some patients are prevented from continuing effect treatment owing to the severe adverse events experienced. We support the opinion that the influence of these factors should be noted in the discussion and comparison of biological activities of honey products [19]. A majority of the country thinks that at least 20 percent of Americans at least one in five of us are gay or lesbian. For example, although several studies have shown that RJ tended to suppress the tumor growth of astrocytoma, glioblastoma multiforme, astroglia and colorectal cancer cells, these anti-cancer effects are not always recognized to be significant and RJ monotherapy is not recommended [27,28]. The effect of royal jelly on the growth of breast cancer in mice Unfortunately, the relationship between such changes and anti-cancer agent-induced toxicities in normal tissues is not well characterized. Zhang B., Fang C., Deng D., Xia L. Research progress on common adverse events caused by targeted therapy for colorectal cancer. Therefore, more detailed investigations are essential for a discussion of the clinical utility of RJ in these patients. Interestingly, it was also shown that RJ reversed the histopathological alterations induced by BLM and increased the anti-fibrotic cytokine, interferon (IFN)-, in BALF that was decreased by BLM [43]. For example, it is reported that the cytotoxic effect of temozolomide (TMZ), which is an alkylating cytostatic drug, in a human glioma cell line was increased by the combination of TMZ and RJ [27]. Osama H., Abdullah A., Gamal B., Emad D., Sayed D., Hussein E., Mahfouz E., Tharwat J., Sayed S., Medhat S., et al. These studies also showed that CDDP led to significant histological changes of congestion, dilatation, epithelial vacuolization and infiltration of some immune cells, mostly macrophages, lymphocytes and plasma cells in the kidney tissues; however, these changes were decreased by RJ [47,49]. Influence of royal jelly on the reproductive function of puberty male rats. Bincoletto C., Eberlin S., Figueiredo C.A., Luengo M.B., Queiroz M.L. Cisplatin (cis-diamminedichloroplatinum; CDDP) is an effective synthetic-spectrum anti-cancer agent and is often included in standard regimens for many solid tumors. Unexpectedly, significantly inhibition of cancer-related characteristics is not commonly reported in the case of RJ monotherapy. Several reports have also suggested that some fractions of RJ are potential therapeutic agents for various types of malignancies. Royal jelly contains proteins, peptides, lipids, phenols, flavonoids and other bioactive substances. It is reported that some anti-cancer agents cause significant adverse events, even when administered at a low dosage [41,42]. At present, various chemical substances and environmental hormones that are present in a variety of plastic products, food and beverage containers and many products in house and work place, are speculated to be associated with tumorigenesis [25,82]. Cancer is one of the major causes of death globally. Malekinejad H., Ahsan S., Delkhosh-Kasmaie F., Cheraghi H., Rezaei-Golmisheh A., Janbaz-Acyabar H. Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats. The authors speculated that the anti-oxidant properties of RJ exerted positive effects on these parameters [44]. Miyamoto Y., Shimada K., Sakaguchi Y., Miyamoto M. Cisplatin (CDDP)-induced acute toxicity in an experimental model of hepatic fibrosis. Subsequently, we have summarized the usefulness of RJ in the prevention of anti-cancer treatment-induced toxicities in animal models and patients with cancer. Studies show that royal jelly fights cancer, improves blood health, and Active components and biological functions of royal jelly It results in a significant prolongation of the lifespan of the queen honeybee compared with the worker honeybees through anti-inflammatory, anti-oxidant and anti-microbial activities Antioxidant: Royal jelly contains concentrated levels of several antioxidants. 2. Royal jelly and its active ingredients improve cancer, obesity, Alzheimer's disease and other diseases. Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced For the study, a group of 40 men were administered 38 mg of RJ over a period of three months, their PSA values . Supplements can improve immunity, skin collagen production, wound healing, memory, hormone and cholesterol balance. Prostate cancer patients should also use caution as royal jelly increased testosterone levels in animal studies(19). In rats treated by MTX, the plasma MDA levels in the MTX and RJ-treated group were significantly lower than those in the MTX-treated group and the plasma levels of SOD and GSH-Px in the MTX and RJ-treated group were higher than those in MTX-treated group [52]. Royal Jelly: Beneficial Properties and Synergistic Effects with Chemotherapeutic Drugs with Particular Emphasis in Anticancer Strategies by Suzy Salama 1, Qiyang Shou 2,*, Aida A. Abd El-Wahed 3, Nizar Elias 4, Jianbo Xiao 5, Ahmed Swillam 6, Muhammad Umair 7, Zhiming Guo 8, Maria Daglia 9,10, Kai Wang 11, Shaden A. M. Khalifa 12,* and The induction of such changes at the molecular level by RJ are speculated to confer the protective effects of renal function because such pro-fibrotic changes are closely associated with CDDP-induced nephrotoxicity [77]. Improved glucose tolerance and erythropoiesis occur from accelerated conversion of DHEA-S to testosterone via activation of 3-HSD2 and/or 17-HSD3(32). Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Liu J.R., Yang Y.C., Shi L.S., Peng C.C. Other data suggest it may improve type 2 diabetes(23)(24) or cardiometabolic markers(33), but a meta-analysis determined that supplementation does not improve glucose levels(34), and quality of evidence is generally low(35). First, the anti-cancer effects of RJ in cancer cell lines should be considered. 10-HDA (Figure 1) is a major component of RJ and is known to have various biological activities [37]. Cornara L., Biagi M., Xiao J., Burlando B. Furthermore, PGE2 is an important modulator for the activities of immune cells, including macrophages, dendritic cells and natural killer cells [34,35,36]. Another small study suggests benefit with topical royal jelly ointment in head and neck cancer patients(30). Accessibility Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Townsend G.F., Morgan J.F., Hazlett B. Effect of royal jelly on experimental colitis Induced by acetic acid and alteration of mast cell distribution in the colon of rats. But how this "queen magic" actually happens, and its potential benefit to humans, has remained a mystery to scientists. Royal Jelly . Royal jelly has estrogenic effects in vitro and in vivo. according to the Memorial Sloan Kettering Cancer Center. In regard to oxidative stress, RJ was shown to exert no significant influence on MDA and GSH levels in the kidney of mice under physiological conditions [66]. Indeed, RJ composition varies by countries; for examples, the percentage of 10-HDA content in Brazil tended to be higher than that in other countries, including Japan, India, Turkey and Switzerland [38]. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial. Cancer-fighting properties - According to a study published in a 2009 edition of the BMC Complementary and Alternative Medicine, royal jelly fights cancer by suppressing the blood supply to tumors. RJ has also been demonstrated to be useful for suppression of adverse events, the maintenance of the quality of life during treatment and the improvement of prognosis in animal models and patients with malignancies. Preclinical studies suggest royal jelly may reduce blood pressure, cholesterol levels, and inflammation. 8 Potential Health Benefits of Royal Jelly | Organic Facts With regarding RJ, it is reported that RJ has anti-environmental estrogen activity against effects induced by bisphenol A (BPA) in MCF-7 human breast cancer cells. Users of this Web site should not rely on information provided on this Web site for their own health problems. Previously, we introduced combined therapies of RJ and other anti-cancer agents. As a library, NLM provides access to scientific literature. In contrast, there is no general agreement on the best administration method to produce the anti-cancer and/or protective effects of RJ in patients with malignancies. Effects of an herbal medication containing bee products on menopausal symptoms and cardiovascular risk markers: results of a pilot open-uncontrolled trial. Evidence Based 12 Potential Health Benefits of Royal Jelly Royal jelly is a gelatinous substance produced by honey bees to feed the queen bees and their young. Yoneshiro T., Kaede R., Nagaya K., Aoyama J., Saito M., Okamatsu-Ogura Y., Kimura K., Terao A. Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. For example, there is a report that among the two protein fractions obtained from the protein extract of RJ precipitated with 30% and 60% ammonium sulfate (called RJP30 and RJP60, respectively), the survival of human cervical cancer cells (HeLa) was inhibited by RJP30 but not by RJP60 [80]. The function of RJ may be attributed to its major and unique fatty acid, 10-hydroxy-2-decenoic acid (10-HDA). Suppressed damage through an increase in the activities of anti-oxidant factors, Conferred protection against histopathological and biochemical alterations. In addition, this study also showed that levels of malondialdehyde (MDA), which is commonly used as biomarker of oxidative stress [73], were significantly lower in the kidney or liver tissues of rats treated with CDDP and RJ than those treated with CDDP. With regard to cell proliferation, there was a report that the expression of bromodeoxyuridine (BrdU), which is commonly used as a marker of cell proliferation, was downregulated in renal tubular epithelial cells by CDDP administration in rats; however, this change was restored by dietary RJ administration [49]. Effect of royal jelly on bisphenol A-induced proliferation of human Effect of Royal Jelly Intake on Serum Glucose, Apolipoprotein A-I (ApoA-I), Apolipoprotein B (ApoB) and ApoB/ApoA-I Ratios in Patients with Type 2 Diabetes: A Randomized, Double-Blind Clinical Trial Study. Other investigators have also shown that RJ reversed TGF- levels in the BALF of rats treated with BLM [43]; unexpectedly, they also found that significant activity was detected in in rats orally administered RJ at 50 and 100 mg/kg/day but not at 25 mg/kg/day. Efficacy of royal jelly on methotrexate-induced systemic oxidative stress and damage to small intestine in rats. The GSH-Px level in the prostate was significantly higher in rats administered with cyclophosphamide and RJ than those administered cyclophosphamide only [51] and similar findings was also reported in the lung of rats treated with bleomycin [43]. Cancer A study on propolis supplementation for colon cancer prevention in high-risk patients found no benefit, and actually indicated potential negative effects on muscle tissues including heart muscle cells. Daenen K., Andries A., Mekahli D., Van Schepdael A., Jouret F., Bammens B. Oxidative stress in chronic kidney disease.